File:Triad mechanism.svg

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DescriptionTriad mechanism.svg	English: General reaction mechanism of catalysed by a catalytic triad (black): nucleophilic substitution at a carbonyl substrate (red) by a second substrate (blue). First, the enzyme's nucleophile (X) attacks the carbonyl to form a covalently linked acyl-enzyme intermediate. This intermediate is then attacked by the second nucleophile (X') of the second substrate. If the second nucleophile is the hydroxyl of water, the result is hydrolysis, otherwise the result is group transfer of X'.
Date	16 August 2015
Source	Thomas, Shafee, (2014). "Evolvability of a viral protease: experimental evolution of catalysis, robustness and specificity". PhD Thesis. University of Cambridge.
Author	Thomas Shafee
Other versions	For unannotated version see File:Triad mechanism unannotated.svg

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current	11:16, 20 August 2015	1,225 × 221 (225 KB)	Evolution and evolvability	slightly smaller text size
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